Malusi Siboto took 7-48 for the Titans to topple the Lions for 206 on day one of their Sunfoil Series clash in Potchefstroom.
The table-topping Titans, looking to maintain their spot at the top of the table going into the second half of the campaign in January as they seek back-to-back titles, got off to a rollicking start against the Lions.
Rowan Richards and Siboto smashed the top order, taking two wickets each, with only 29 runs on the board.
SA U19 batsman Yaseen Valli and all-rounder Dwaine Pretorius brought the Lions back into the game, putting on 89 for the fifth-wicket partnership which was ended by David Wiese, grabbing the wicket of Valli for 40.
Pretorius proved his worth with the bat once again, reaching his fourth half-century in just three matches, as he anchored a sixth-wicket partnership of 68 with Mangaliso Mosehle (41).
Siboto stepped up to dismiss Mosehle the over before tea and Pretorius in his first over after the break. Pretorius had run up a valuable 72, off 124 balls, with 11 fours.
Siboto then bowled three more overs, crushing the tail with a wicket in each.
The Titans trail by 172 at stumps on day one and will resume their innings on 34-0 with Heino Kuhn on 27 and back-to-back centurion Aiden Markram on seven.
Elsewhere, a 91-run second-wicket partnership between Colin Ackermann and Dionne Koopman (41) set the tone for the Warriors in their match against the Knights in Port Elizabeth. The home side posted 292-7 at stumps, thanks to Ackermann and Lesiba Ngoepe, who both top scored with 71.
Marchant de Lange and Shadley van Schalkwyk picked up seven wickets between them, De Lange with 3-65 and Van Schalkwyk with 4-59.
The Cobras, without a win so far this season, got off to a good start against the Dolphins as Dane Paterson tore through the top order, taking 4-46 Vaughn van Jaarsveld provided some resistance, scoring 56 before he fell to Dane Piedt .
Khaya Zondo has been in fine form for the Dolphins this season with three fifties to his name going into this clash, and he continued that form emphatically with the knock of the day, smashing his side out of a rut by scoring 139, as he remains unbeaten with his partner, Morne van Wyk, on 37. The Dolphins ended the day on 285-5.
Photo: Sydney Mahlangu/BackpagePix