Keegan Petersen struck his second half-century of the series on day one of the second four-day match between South Africa A and the West Indies A in East London.
The Proteas batsman scored 67 off 124 balls, with eight fours, as SA A closed on 266-6.
Raynard van Tonder (50) and Tony de Zorzi (44) were also among the runs for the hosts.
Shamar Joseph (2-39), Kevin Sinclair (2-49) and Jair McAllister (2-68) were the pick of the bowlers.
The visitors, who lead the three-match series 1-0, won the toss and opted to field first when mist caused an early delay.
Only 33 minutes of play were possible in the first session due to the poor visibility with an early lunch called for bad light and the score on 18-0.
The West Indies A struck early on after the break when Joseph trapped SA A captain Neil Brand lbw for four.
De Zorzi and Van Tonder then combined for a 65-run partnership spanning 20.4 overs, before Sinclair had De Zorzi caught by Zachary McCaskie at short leg.
Van Tonder was joined by Petersen and brought up his 50 off 83 balls with his ninth boundary of the innings, but fell three balls later to McAllister as he held on off his own bowling.
Petersen and Proteas batsman Khaya Zondo looked well set in their fourth-wicket stand of 86 runs, but it was Joseph who eventually got the breakthrough for the West Indies A as Petersen played one square to Sinclair at point.
That wicket soon brought another as Zondo (35 off 91 balls, five fours and one six) fell within the next three overs as he pulled one off Sinclair into the hands of the sub fielder Shermon Lewis at short fine leg.
Sinclair continued to make his mark on the game as he held on to a catch off McAllister to dismiss Clyde Fortuin for 12.
Ruan de Swardt (25*) and Mihlali Mpongwana (12*) ensured no further wickets fell before the close.
