England beat the Proteas by 109 runs in Leicester on Monday to complete a 3-0 women’s ODI series win.
The hosts posted a massive 371-7 in their 50 overs thanks to a superb century by Tammy Beaumont (119 off 107 balls) and half-centuries from Emma Lamb (65 off 66), Sophia Dunkley (51 off 53) and captain Heather Knight (63 off 49).
Ayabonga Khaka took 2-64 in her 10 overs for South Africa, while Shabnim Ismail, Nadine de Klerk and Nonkululeko Mlaba each picked up a wicket.
The Proteas made a solid start to their run chase with an opening partnership of 61 by Andrie Steyn (12) and Lara Wolvaardt (56 off 51 balls), both of whom were dismissed by Charlie Dean.
When England removed Lara Goodall (24) and captain Sune Luus (nine), the Proteas were 109-4 after 20.2 overs.
The in-form Marizanne Kapp (62 off 54 balls) and Chloe Tryon (70 off 57) then took the total to 219 in the 36th over before the former was caught.
Tryon managed a few more lusty blows before heading back to the change room, and England then quickly wrapped up the Proteas innings, with Dean, Lamb and Alice Davidson-Richards finishing with three wickets each.
The teams will now meet in a three-match T20I series, starting in Chelmsford on Thursday.