Proteas captain Temba Bavuma is unavailable for selection for the fourth ODI in Centurion on Friday.
The opening batsman has a right adductor strain and will miss the match as a precautionary measure.
Aiden Markram will captain the side in Bavuma’s absence.
Meanwhile, fast bowler Anrich Nortje has been ruled out of the remaining two matches of the series due to a lower back injury.
The 29-year-old underwent scans and consulted with a specialist this week, and will start bowling again this weekend under the supervision of the Proteas medical team.
Friday’s match will start at 1pm.