Proteas captain Temba Bavuma and spinner Tabraiz Shamsi have been ruled out of the second ODI against India in Ranchi.
Both players have a mild infection.
Bjorn Fortuin, Rilee Rossouw and Tristan Stubbs have been added to the squad.
South Africa are 1-0 up in the three-match series after winning the opening ODI by nine runs.
LIVE: India vs Proteas (2nd ODI)