Zubayr Hamza has tested positive for a prohibited substance under the ICC anti-doping code.
The positive test followed an ICC anti-doping test on 17 January.
The Proteas batsman is not disputing the positive test, is co-operating fully with the ICC, and has agreed to a voluntary suspension commencing immediately while written submissions are presented to the ICC.
The positive test relates to the substance furosemide, which is not a performance-enhancing substance, and Zubayr has been able to identify how the substance entered his system.
The process to follow will entail presenting evidence that there was no fault or negligence, or no significant fault or negligence on the part of Zubayr.